Treatment Services

Preimplantation Genetic Testing

What is Pre-implantation Genetic Screening (PGS)?

Even though there are no chromosomal abnormalities detected for both partners, chromosomal abnormalities in the eggs or sperm may still occur during spermatogenesis or ovulation, producing an embryo with chromosomal abnormalities. Such embryos may fail to implant or abortion may happen easily even after implantation. The ratio ofchromosomal abnormalities in the eggs is proportional to female age. In other words, there is an increased ratio of chromosomal abnormalities in the eggs of women as they age. PGS is intended to examine the embryo’s chromosome so as to transfer embryos with normal chromosome in order to increase the pregnancy rate and reduce the miscarriage rate.

What is Pre-implantation Genetic Diagnosis (PGD)?

Both partners are known to have familial diseases or suffer from known genetic diseases or are carriers for known genetic diseases. In order to protect the coming babies from the same diseases, PGD is utilized to examine certain genetic diseases of the embryo and to transfer embryos without illness.

Pre-implantation Genetic Screening
Indications 1.Subjects of advanced age
2.habitual abortion
3.multiple IVF failures
4.history of chromosomal abnormalities
5.sex-linked diseases
Note Embryo biopsy may not completely exclude the possibility of harming the embryo. Besides, sufficient evidence is lacking to prove that PGS contributes to the absolute benefits to all IVF populations. Thus, it is advised to consult with the doctor about whether you should proceed with the screening.
Pre-implantation Genetic Diagnosis
Indications 1.Couples with known familial diseases or carriers
2.Balanced chromosome translocation
Note Both partners will be arranged for pre-IVF testing at the Department of Genetic Medicine at CCH. The purpose of this pre-testing is to tailor-make the probe of the examination. The probe design takes approximately one month.

Process briefing

Process briefing
  • 1Both partners come to the Department of Genetic Medicine for a blood test and pre-testing. (The probe design takes approximately one month.)
  • 2Beginning of the IVF procedure.(link to the IVF procedure).
  • 3Fertilized embryos are all cultured to Day 5 as the blastocyst stage. The biopsy is performed to hatch blastocysts.
  • 4Specimens are sent to the Department of Genetic Medicine at CCH for examination.
  • 5The report will be released the next day. The embryos with normal results will be selected and transferred.
    If the female partner is not suitable for fresh embryo transfer, the embryo will be frozen after biopsy for subsequent transfer.
    If the biopsy day of the Day 5 blastocysts is on the weekend or a closed day of the hospital, the biopsy will be postponed and the embryo will be frozen for the next suitable cycle to be thawed for the biopsy. The normal embryos will be transferred the next day of the examination.