About Doctor

醫師介紹

胸腔內科 - 林聖皓主治醫師

學經歷

學歷:

國立中興大學生物醫學研究所博士

中國醫藥學院中醫學系

教職:教育部部定助理教授


經歷:

彰化基督教醫院睡眠醫學中心主任

彰化基督教醫院臨床試驗中心主任、執行長

台中榮民總醫院嘉義分院胸腔內科主治醫師

台中榮民總醫院胸腔內科總醫師、臨床研究醫師

台中榮民總醫院內科部住院醫師


現任:

內科部副主任

胸腔內科主任、主治醫師

臨床試驗中心副主任


專科:

內科專科醫師

胸腔暨重症專科醫師

重症醫學專科醫師

胸腔外科暨重症專科指導醫師

睡眠醫學專科醫師

戒菸治療服務資格

戒菸治療種籽教師資格


進修:

國家衛生研究院免疫醫學中心研習

專長

胸腔症狀 (咳嗽、咳血、胸痛、呼吸困難)

呼吸道感染 (肺炎、膿胸、肺結核、支氣管炎、上呼吸道感染)

慢性肺病 (氣喘病、慢性阻塞性肺病)

肺部腫瘤 (非小細胞肺癌、小細胞肺癌)

胸腔檢查 (肺功能、支氣管鏡、胸腔超音波) 及肺部復健

重症醫學 (呼吸器、非侵襲性通氣)

睡眠呼吸中止疾病

高壓氧治療相關疾病

榮譽

論文:

1.Chen, D. Y., P. S. Song, J. S. Hong, C. L. Chu, I. H. Pan, Y. M. Chen, C. H. Lin, S. H. Lin and C. C. Lin (2013). "Dextromethorphan inhibits activations and functions in dendritic cells." Clin Dev Immunol 2013: 125643.


2.Chen, M. H., W. S. Li, Y. S. Lue, C. L. Chu, I. H. Pan, C. H. Ko, D. Y. Chen, C. H. Lin, S. H. Lin, C. P. Chang and C. C. Lin (2013). "Clitocybe nuda Activates Dendritic Cells and Acts as a DNA Vaccine Adjuvant." Evid Based Complement Alternat Med 2013: 761454.


3.Kuo, M. C., S. H. Lin, C. H. Lin, I. C. Mao, S. J. Chang and M. C. Hsieh (2013). "Type 2 diabetes: an independent risk factor for tuberculosis: a nationwide population-based study." PLoS One 8(11): e78924.


4.Lee, C. T., I. C. Mao, C. H. Lin, S. H. Lin and M. C. Hsieh (2013). "Chronic obstructive pulmonary disease: a risk factor for type 2 diabetes: a nationwide population-based study." Eur J Clin Invest 43(11): 1113-1119.


5.Lin, S., B. Ji, Y. Shih, C. Chen, P. Chan, Y. Chang, Y. Lin and C. Lin (2013). "Comorbid pulmonary disease and risk of community-acquired pneumonia in COPD patients." The International journal of tuberculosis and lung disease 17(12): 1638-1644.


6.Chen, C. M., P. Y. Lin, Y. C. Chen, Y. Jin, A. P. Huang, S. H. Lin, M. T. Hsing, Y. P. Cheng, C. Y. Cheng and C. T. Lin (2014). "Effects of teriparatide on lung function and pain relief in women with multiple osteoporotic vertebral compression fractures." Surg Neurol Int 5(Suppl 7): S339-342.


7.Chung, T. W., K. T. Tan, H. L. Chan, M. D. Lai, M. C. Yen, Y. R. Li, S. H. Lin and C. C. Lin (2014). "Induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non-small cell lung cancer cells." Asian Pac J Cancer Prev 15(18): 7995-8001.


8.Wu, C. S., G. S. Chen, P. Y. Lin, I. H. Pan, S. T. Wang, S. H. Lin, H. S. Yu and C. C. Lin (2014). "Tazarotene induces apoptosis in human basal cell carcinoma via activation of caspase-8/t-Bid and the reactive oxygen species-dependent mitochondrial pathway." DNA Cell Biol 33(10): 652-666.


9.Chou, H. C., J. Y. Chen, D. Y. Lin, Y. F. Wen, C. C. Lin, S. H. Lin, C. H. Lin, T. W. Chung, E. C. Liao, Y. J. Chen, Y. S. Wei, Y. T. Tsai and H. L. Chan (2015). "Identification of Up- and Down-Regulated Proteins in Pemetrexed-Resistant Human Lung Adenocarcinoma: Flavin Reductase and Calreticulin Play Key Roles in the Development of Pemetrexed-Associated Resistance." J Proteome Res 14(11): 4907-4920.


10.Lin, C.-H., S. H. Lin, C.-C. Lin, Y.-C. Liu, C.-J. Chen, C.-L. Chu, H.-C. Huang and M.-K. Lin (2016). "Inhibitory effect of clove methanolic extract and eugenol on dendritic cell functions." Journal of functional foods 27: 439-447.


11.Lin, S. H., D. W. Perng, C. P. Chen, W. H. Chai, C. S. Yeh, C. T. Kor, S. L. Cheng, J. J. Chen and C. H. Lin (2016). "Increased risk of community-acquired pneumonia in COPD patients with comorbid cardiovascular disease." Int J Chron Obstruct Pulmon Dis 11: 3051-3058.


12.Lin, S. H., B. Y. Wang, C. H. Lin, P. J. Chien, Y. F. Wu, J. L. Ko and J. J. Chen (2016). "Chidamide alleviates TGF-β-induced epithelial-mesenchymal transition in lung cancer cell lines." Mol Biol Rep 43(7): 687-695.


13.Wang, B. Y., Y. C. Chang, Y. C. Chang, K. M. Wang, C. H. Lin, S. H. Lin and W. C. Lin (2016). "Thoracoscopic surgery via a single-incision subxiphoid approach is associated with less postoperative pain than single-incision transthoracic or three-incision transthoracic approaches for spontaneous pneumothorax." J Thorac Dis 8(Suppl 3): S272-278.


14.Wang, B. Y., J. Y. Huang, W. H. Hung, C. H. Lin, S. H. Lin, Y. P. Liaw and J. L. Ko (2016). "Impact on Survival on Interval between Surgery and Adjuvant Chemotherapy in Completely Resected Stage IB-IIIA Lung Cancer." PLoS One 11(11): e0163809.


15.Wang, B. Y., J. Y. Huang, C. H. Lin, J. L. Ko, C. T. Chou, Y. C. Wu, S. H. Lin and Y. P. Liaw (2016). "Thoracoscopic Lobectomy Produces Long-Term Survival Similar to That with Open Lobectomy in Cases of Non-Small Cell Lung Carcinoma: A Propensity-Matched Analysis Using a Population-Based Cancer Registry." J Thorac Oncol 11(8): 1326-1334.


16.Chung, T. W., Y. R. Li, W. Y. Huang, J. H. Su, H. L. Chan, S. H. Lin, C. S. Liu, S. C. Lin, C. C. Lin and C. H. Lin (2017). "Sinulariolide suppresses LPS?induced phenotypic and functional maturation of dendritic cells." Mol Med Rep 16(5): 6992-7000.


17.Chung, T. W., J. H. Su, C. C. Lin, Y. R. Li, Y. H. Chao, S. H. Lin and H. L. Chan (2017). "24-Methyl-Cholesta-5,24(28)-Diene-3β,19-diol-7β-Monoacetate Inhibits Human Small Cell Lung Cancer Growth In Vitro and In Vivo via Apoptosis Induction." Mar Drugs 15(7).


18.Huang, H.-C., W.-J. Su, C.-L. Chiang, J.-Y. Feng, H.-Y. Huang, C.-H. Lin, S.-H. Lin, C.-Y. Cheng and C.-H. Chiu (2018). "The predictive value of the interferon-γ release assay for chemotherapy responses in patients with advanced non-small-cell lung cancer." Lung Cancer 115: 64-70.


19.Huang, H. C., W. J. Su, C. L. Chiang, J. Y. Feng, H. Y. Huang, C. H. Lin, S. H. Lin, C. Y. Cheng and C. H. Chiu (2018). "The predictive value of the interferon-γ release assay for chemotherapy responses in patients with advanced non-small-cell lung cancer." Lung Cancer 115: 64-70.


20.Lin, M. X., S. H. Lin, C. C. Lin, C. C. Yang and S. Y. Yuan (2018). "In Vitro and In Vivo Antitumor Effects of Pyrimethamine on Non-small Cell Lung Cancers." Anticancer Res 38(6): 3435-3445.


21.Lin, C. H., S. C. Kuo, M. C. Hsieh, S. Y. Ho, I. J. Su, S. H. Lin, C. Y. Chi, S. L. Su, C. Y. Liao, Y. C. Chen, S. R. Hsu, Y. C. Huang, F. C. Tseng, S. Y. Wang, H. Y. Dou, S. D. Lin, J. S. Lin, S. T. Tu and Y. P. Yeh (2019). "Effect of diabetes mellitus on risk of latent TB infection in a high TB incidence area: a community-based study in Taiwan." BMJ Open 9(10): e029948.


22.Sun, L., J. Fu, S. Lin, J. Sun, L. Xia, C. Lin, L. Liu, C. Zhang, L. Yang and P. Xue (2019). "PM2. 5 disturbs the balance of Th17/Treg cells by targeting Got1 and HIF-1alpha in an asthma model." J Allergy Clin Immunol 10.


23.Tan, K. T., P. W. Chen, S. Li, T. M. Ke, S. H. Lin and C. C. Yang (2019). "Pterostilbene inhibits lung squamous cell carcinoma growth in vitro and in vivo by inducing S phase arrest and apoptosis." Oncol Lett 18(2): 1631-1640.


24.Tan, K. T., S. Li, Y. R. Li, S. L. Cheng, S. H. Lin and Y. T. Tung (2019). "Synergistic Anticancer Effect of a Combination of Paclitaxel and 5-Demethylnobiletin Against Lung Cancer Cell Line In Vitro and In Vivo." Appl Biochem Biotechnol 187(4): 1328-1343.


25.Tan, K. T., M. X. Lin, S. C. Lin, Y. T. Tung, S. H. Lin and C. C. Lin (2019). "Sinensetin induces apoptosis and autophagy in the treatment of human T-cell lymphoma." Anticancer Drugs 30(5): 485-494.


26.Chai, W. H., Y. R. Li, S. H. Lin, Y. H. Chao, C. H. Chen, P. C. Chan and C. H. Lin (2020). "Antihelminthic Niclosamide Induces Autophagy and Delayed Apoptosis in Human Non-small Lung Cancer Cells In Vitro and In Vivo." Anticancer Res 40(3): 1405-1417.


27.Chen, C. H., Y. R. Li, S. H. Lin, H. H. Chang, W. H. Chai, P. C. Chan and C. H. Lin (2020). "Tiotropium/Olodaterol treatment reduces cigarette smoke extract-induced cell death in BEAS-2B bronchial epithelial cells." BMC Pharmacol Toxicol 21(1): 74.


28.Cheng, Y. F., W. H. Hung, H. C. Chen, C. Y. Cheng, C. H. Lin, S. H. Lin and B. Y. Wang (2020). "Comparison of Treatment Strategies for Patients With Clinical Stage T1-3/N2 Lung Cancer." J Natl Compr Canc Netw 18(2): 143-150.


29.Lin, C. H., P. J. Yang, S. H. Lin, K. T. Yeh, T. C. Tsao, Y. E. Chen, S. H. Lin and S. F. Yang (2020). "Association between EGFR Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer." Diagnostics (Basel) 10(9).


30.Sun, L., J. Fu, S. H. Lin, J. L. Sun, L. Xia, C. H. Lin, L. Liu, C. Zhang, L. Yang, P. Xue, X. Wang, S. Huang, X. Han, H. L. Chen, M. S. Huang, X. Zhang, S. K. Huang and Y. Zhou (2020). "Particulate matter of 2.5 μm or less in diameter disturbs the balance of T(H)17/regulatory T cells by targeting glutamate oxaloacetate transaminase 1 and hypoxia-inducible factor 1α in an asthma model." J Allergy Clin Immunol 145(1): 402-414.


31.Wang, B. Y., J. Y. Huang, H. C. Chen, C. H. Lin, S. H. Lin, W. H. Hung and Y. F. Cheng (2020). "The comparison between adenocarcinoma and squamous cell carcinoma in lung cancer patients." J Cancer Res Clin Oncol 146(1): 43-52.


32.Chang, K. W., X. Zhang, S. C. Lin, Y. C. Lin, C. H. Li, I. Akhrymuk, S. H. Lin and C. C. Lin (2021). "Atractylodin Suppresses TGF-β-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice." Int J Mol Sci 22(20).


33.Chen, C. Z., C. C. Sheu, S. L. Cheng, H. C. Wang, M. C. Lin, W. H. Hsu, K. Y. Lee, D. W. Perng, H. I. Lin, M. S. Lin, S. H. Lin, J. R. Tsai, C. C. Wang, C. Y. Wang, T. M. Yang, C. L. Liu, T. Y. Wang and C. H. Lin (2021). "Performance and Clinical Utility of Various Chronic Obstructive Pulmonary Disease Case-Finding Tools." Int J Chron Obstruct Pulmon Dis 16: 3405-3415.


34.Cheng, S. L., K. C. Chiu, H. K. Ko, D. W. Perng, H. C. Wang, C. J. Yu, C. C. Sheu, S. H. Lin and C. H. Lin (2021). "Comparing Patient Characteristics, Clinical Outcomes, and Biomarkers of Severe Asthma Patients in Taiwan." Biomedicines 9(7).


35.Cheng, S. L., Y. R. Li, N. Huang, C. J. Yu, H. C. Wang, M. C. Lin, K. C. Chiu, W. H. Hsu, C. Z. Chen, C. C. Sheu, D. W. Perng, S. H. Lin, T. M. Yang, C. B. Lin, C. T. Kor and C. H. Lin (2021). "Effectiveness of Nationwide COPD Pay-for-Performance Program on COPD Exacerbations in Taiwan." Int J Chron Obstruct Pulmon Dis 16: 2869-2881.


36.Cheng, S. L., C. H. Lin, K. A. Chu, K. L. Chiu, S. H. Lin, H. C. Lin, H. K. Ko, Y. C. Chen, C. H. Chen, C. C. Sheu, W. C. Huang, T. M. Yang, Y. F. Wei, J. Y. Chien, H. C. Wang and M. C. Lin (2021). "Update on guidelines for the treatment of COPD in Taiwan using evidence and GRADE system-based recommendations." J Formos Med Assoc 120(10): 1821-1844.


37.Chung, C. L., W. C. Huang, H. L. Huang, C. S. Chin, M. H. Cheng, M. R. Lee, S. H. Lin, J. Y. Wang, C. H. Lin, I. W. Chong, J. Y. Shih and C. J. Yu (2021). "Subsequent Antituberculous Treatment May Not Be Mandatory Among Surgically Resected Culture-Negative Pulmonary Granulomas: A Retrospective Nationwide Multicenter Cohort Study." Open Forum Infect Dis 8(12): ofab565.


38.Goldman, J. W., M. Dvorkin, Y. Chen, N. Reinmuth, K. Hotta, D. Trukhin, G. Statsenko, M. J. Hochmair, M. Ozguro?lu, J. H. Ji, M. C. Garassino, O. Voitko, A. Poltoratskiy, S. Ponce, F. Verderame, L. Havel, I. Bondarenko, A. Ka?arnowicz, G. Losonczy, N. V. Conev, J. Armstrong, N. Byrne, P. Thiyagarajah, H. Jiang and L. Paz-Ares (2021). "Durvalumab, with or without tremelimumab, plus platinum-etoposide versus platinum-etoposide alone in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): updated results from a randomised, controlled, open-label, phase 3 trial." Lancet Oncol 22(1): 51-65.


39.Huang, Y. H., J. Y. Hung, H. W. Ko, P. L. Su, C. L. Lai, H. C. Chang, T. C. Hsia, S. H. Lin, K. L. Wu, C. T. Yang, W. C. Su, Y. C. Chu, C. C. Wang, W. Y. Liao, Y. T. Lin, C. H. Lin, M. C. Lin, K. H. Hsu, J. S. Tseng, T. Y. Yang, K. C. Chen, M. H. Lee, S. L. Yu, C. C. Ho and G. C. Chang (2021). "The relative importance of predictive factors for single first-generation EGFR-TKI use for more than 5 years in patients with advanced non-small cell lung cancer: Taiwan multicenter TIPS-5 study." Ther Adv Med Oncol 13: 17588359211018022.


40.Ko, H. K., S. L. Cheng, C. H. Lin, S. H. Lin, Y. H. Hsiao, K. C. Su, C. J. Yu, H. C. Wang, C. C. Sheu, K. C. Chiu and D. W. Perng (2021). "Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma." Sci Rep 11(1): 8425.


41.Lin, C. H., S. L. Cheng, H. C. Wang, W. H. Hsu, K. Y. Lee, D. W. Perng, H. I. Lin, M. S. Lin, J. R. Tsai, C. C. Wang, S. H. Lin, C. Y. Wang, C. Z. Chen, T. M. Yang, C. L. Liu, T. Y. Wang and M. C. Lin (2021). "Novel App-Based Portable Spirometer for the Early Detection of COPD." Diagnostics (Basel) 11(5).


42.Cheng, W. C., Y. Wen, Y. S. Chiu, C. H. Chou, C. J. Lim, S. H. Lin, J. M. Chang and C. C. Lin (2022). "Pendulone induces apoptosis via the ROS-mediated ER-stress pathway in human non-small cell lung cancer cells." Toxicol In Vitro 81: 105346.


43.Kor, C. T., Y. R. Li, P. R. Lin, S. H. Lin, B. Y. Wang and C. H. Lin (2022). "Explainable Machine Learning Model for Predicting First-Time Acute Exacerbation in Patients with Chronic Obstructive Pulmonary Disease." J Pers Med 12(2).


44.Lin, C. W., K. Y. Huang, C. H. Lin, B. Y. Wang, C. T. Kor, M. H. Hou and S. H. Lin (2022). "Video-Assisted Thoracoscopic Surgery in Community-Acquired Thoracic Empyema: Analysis of Risk Factors for Mortality." Surg Infect (Larchmt) 23(2): 191-198.

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