Elevated Plasma cyclophilin A and CD147 are associated with poor renal outcome in type 2 diabetes patients in a 11 years follow-up study and probably mediated by inducing mitochondrial dysfunction of mesangial cells.
Ping-Fang Chiu， Shih-Li Su， Chun-Chieh Tsai， Chia-Lin Wu， Chen-Ling Kuo， Chew-Teng Kor， Chia-Chu Chang & Chin-San Liu

Abstract
To find the associations of circulating cyclophilin A (CyP A) and CD147/EMMPRIN with renal outcomes in type 2 diabetes patients and possible pathogenesis involved. Total 131 patients were recruited since 2004. Glycated hemoglobin， blood glucose and urine albumin–creatinine ratio levels at baseline and every 3 months were measured. Plasma CyP A and CD147 were also measured at baseline. Patients were divided into two groups based upon the median level of the baseline plasma CyP A value: < 93.64 ng/mL (group A， n = 65)， ≥ 93.64 ng/mL (group B， n = 66). The estimated glomerular filtration rate was calculated at each follow-up visit. Besides， mitochondrial function assay by cellular mitochondrial energy utility was studied when cells were exposed to glucose or exogenous CyP A or both. Multivariate analysis， using median level (93.64) ng/mL as the cut-off value， revealed that circulating CyP A and CD147 levels at baseline were associated with the baseline estimated glomerular filtration rate (eGFR) (p = .042 and p = .001 separately) in cross-sectional analysis. Longitudinally， higher baseline plasma CyP A level was also correlated to a rapid decline in eGFR (p = .016). The results were also significant when using the continuous plasma CyP A level (p = .003). In cells exposed to glucose， results of oxygen consumption rate (OCR) showed a significant reduction in basal respiration， maximal respiration and ATP production. Depressed OCR further occurred when incubated with both of CyP A and glucose. Plasma CyP A and CD147 can serve as indicators of renal disease progression in type 2 diabetes patients.

資料來源:Free Radic Res. 2018 Dec;52(11-12):1456-1463