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1.   認識腎性骨病變/Understanding Renal Osteodystrophy  2018.06.28

認識腎性骨病變

大家一起來認識腎臟功能有哪些:
1.排泄體內廢物與水份
2.維持人體鈣、磷、鈉、鉀、等電解質平衡
3.分泌紅血球生成素--刺激骨髓製造紅血球
4.活化維生素D---維持骨頭的密度與健康

※什麼是腎性骨病變呢?
當腎臟功能退化至慢性腎臟病第四、五期時,容易導致血液中磷值增加鈣質減少,引發續發性副甲狀腺素升高及腎臟分泌活性維生素D3減少,使骨質合成改變,進而造成骨骼病變。

※發生腎性骨病變有那些症狀?
包含骨骼疼痛、骨質疏鬆、肌肉無力、骨折、血管及組織異常鈣化等。

※血中鈣磷不平衡引發次發性副甲狀腺素升高,會導致骨骼病變外,還會影響其他器官組織嗎? 
答:是的!

1.副甲狀腺素升高,會縮短體內紅血球的壽命而造成貧血,且會減弱改善貧血用藥(EPO:紅血球生成素)的療效。
2.免疫能力減弱及神經傳導的不正常。
3.血管硬化,導致心臟血管疾病。
4.骨質變化,容易骨折。
5.身上受傷處產生鈣化。
6.皮膚癢

※如何得知鈣、磷不平衡?
由抽血檢驗鈣(正常值8.9~10.3mg/dl)、磷(正常值2.4~4.7mg/dl)數值異常。

※如何預防腎性骨病變發生?
1.避免高磷食物來減少磷質攝取量。表(一)含磷食物放大鏡。
2.服用藥物(磷結合劑包含:胃乳片、醋酸鈣或碳酸鈣)減低食物中的磷質被腸道吸收。


*服用胃乳片及碳酸鈣小秘訣:

需在三餐中咬碎與飯菜一起服用,如此食物中的磷質會先與藥物結合就不會被腸道吸收了。


結論:
當腎臟功能(正常值90~100%)剩下30%時開始執行含磷質食物的調整,並依醫囑服用磷結合劑,來減輕慢性腎臟病併發症的腎性骨病變。

學習自我評量
( ) 1.腎性骨病變是體內那些電解質不平衡?
 (1)鹽分 (2)鈣磷 (3)水分
( ) 2.磷結合劑有效的服用方式?(1)飯前服用(2)飯後服用(3)飯中絞碎服用
( )3.下列何者是含磷較高的食物應避免(1)花生、蛋黃 (2)紅蟳、糙米 (3)素火腿、素雞
(4)以上皆是

題號

1 2 3 4 5

正確答案

 (1)

(2)

(1)

 (3)

(4)

 

表(一)含磷食物放大鏡
磷廣泛存在於天然界中,大部份高蛋白質的營養食物都含有磷。磷質可來自動物及植物性食物。其中又以肉、魚、蛋、奶製品、豆類及穀類等食物為主要的來源。儘量避免攝取過量高磷食物,因為再多的藥物也無法完全處理之。

 

參考資料:
高治圻、許巧縈、林彥仲、吳麥斯、陳振文、陳錫賢(2015).慢性腎衰竭病人的鈣、磷代謝異常之飲食對策.腎臟與透析,27(3),107-110。

何韋德.陳薏如、黃錫培、何永和、劉文治、楊麗琼(2015).慢性腎臟病之血管蓋化與治療.腎臟與透析,27(3),129-134。
制定日期:2006年2月
修訂日期:2018年6月(第五版)
編碼:5736-單張-中文-296-05

                  

Understanding Renal Osteodystrophy
認識腎性骨病變


and in cline in phosphorus in our blood, leading to higher secretion of parathyroid hormone and reduction of active vitamin D3, causing changes in bone synthesis and thus bone lesions.

※ What are the symptoms of renal osteodystrophy?Functions of our kidneys are:
1. To excrete waste and water from our body.
2. To keep balance of calcium, phosphorus, sodium, potassium, and other electrolyte level.
3. To secrete erythropoietin for red blood cells production.
4. To activate vitamin D3 --- to maintain bone density and health.

※ What is renal osteodystrophy?
 The degeneration of kidneys can easily cause a decline calcium

The symptoms may include bone pain, osteoporosis, muscle weakness, bone fractures, abnormal calcification of blood vessels and tissues.

※ The imbalance of calcium and phosphorus in blood level would cause an increase of parathyroid hormone, leading to bone disorder. Will it also affect other organs of our body?
A: Yes!
1. The increase of parathyroid hormone will shorten the life span of red blood cells and cause anemia. It will also interact the medical effectiveness of erythropoietin injection.
2. Immunity would decline. Nerve conduction would turn abnormal.
3. The arteries may become stiffness, leading to cardiovascular disease.
4. Bone density may change, leading to fracture easily.
5. Wounds and cuts in our body are prone to calcification.
6. Itchy skin or pruritus.

※ How do I know my calcium and phosphorus are not in balance?
Blood tests will tell. Normal level of calcium ranged around at 8.9 ~ 10.3mg/dl and phosphorus at 2.4 ~ 4.7mg/dl.

※ How can we prevent renal osteodystrophy?
Two key points are:
1. Avoid phosphorus-rich foods to reduce the phosphorus intake. See Table (A) Magnifying glass for phosphorus-rich foods.
2. Take medicine (i.e. phosphate binders, which include antacid or calcium carbonate, calcium acetate) to reduce the absorption of phosphorus in food by the intestine. * Tips: Antacid or calcium carbonate should be taken with meals or snacks, so that phosphorus in food is bound with medicine before it is absorbed by intestinal tract.
Conclusion: When our kidneys function at 30% (normally 90% to 100%), we should start to adjust our meals for the intake of phosphorus and follow the doctor's orders to take phosphate binders to reduce the incidence of renal osteodystrophy caused by the chronic kidney disease.

Table (A) Magnifying glass for phosphorus-rich foods
Phosphorus is widespread in the nature. Most of the high-protein nutritional foods contain phosphorus. Phosphorus derived from animal and plant foods. Among them, meat, fish, eggs, dairy products, beans, and cereals are the main sources. Avoid excessive intake of phosphorus-rich foods, because no medication can fully process it.

編碼:5736-單張-英文-124-02
英文翻譯日期:2017年6月
依據:5736-單張-中文-296-04
中文修訂日期:2015年5月

 

 
H Eat little the following foods
W Avoid eating the following foods
Staple
Rice, bread, white toast
Oatmeal, barley, red beans, mung bean, lotus seeds
Brown rice, embryo rice, instant oatmeal
Meat and fish
Fresh meat, fish, pig blood, duck blood
Clams, oysters, shrimp
Squid, crab
Beans
Tofu pudding, tofu (skin), soy milk
Frozen tofu
Black beans, vegetarian ham, vegetarian chicken
Eggs
Egg white
Whole egg
Yolk
Dairy products
Fresh milk-
Cheese, Yakult, yogurt
Cream, butter, bacon, goat milk tablets
Processed foods
-
Floss, fish floss
Milkfish balls, sausages, Yan dumplings, pork balls
Snacks, nuts
-
-
Peanuts, melon seeds, water chestnuts,
vita yeast sugar, beans, cashew nuts, lactic acid
Beverage
-
-
Coke, SARS, soft drinks, tea, coffee
Seasoning
-
-
Barbeque sauce, sesame paste, oyster sauce
Health Food
-
-
Lecithin

需在三餐中咬碎與飯菜一起服用,如此食物中的磷質會先與藥物結合就不被腸道吸收了。
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